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Humanized Mediator Release Assay as a Read-Out for Allergen Potency
Published on: June 29, 2021
Germinal-centre reactions in allergic inflammation.
Hannah J Gould1, Pooja Takhar, Helen E Harries
1Randall Division of Cell and Molecular Biophysics, King's College London, UK. hannah.gould@kcl.ac.uk
Trends in Immunology
|September 5, 2006
Summary
A third stage of immune response, involving tertiary lymphoid organs, occurs at sites of chronic inflammation. These germinal-center-like reactions are now recognized in allergic inflammation, expanding our understanding of immune responses.
Area of Science:
- Immunology
- Pathology
Background:
- Primary and secondary immune responses occur in lymphoid organs.
- Tertiary lymphoid organs develop at sites of chronic inflammation.
- Germinal-center-like reactions are known in autoimmune diseases.
Purpose of the Study:
- To review evidence for germinal-center-like reactions in tertiary lymphoid organs during allergic inflammation.
Main Methods:
- Literature review of recent evidence.
Main Results:
- Tertiary lymphoid organs form in response to persistent local antigen challenge.
- Germinal-center-like reactions are documented in autoimmune disease targets.
- Evidence suggests these reactions also occur in allergic inflammation sites.
Conclusions:
- Tertiary lymphoid organs represent a third stage of immune response.
- Germinal-center-like reactions are implicated in allergic inflammation.
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