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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

The p53 knowledgebase: an integrated information resource for p53 research

Y P Lim1, T T Lim, Y L Chan

  • 1Bioinformatics Institute, Matrix, Singapore, Singapore.

Oncogene
|September 6, 2006
PubMed

Insights

The p53 tumor suppressor protein, the guardian of the genome, is crucial for genomic integrity. A new knowledgebase centralizes p53 data to aid cancer research.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • The p53 tumor suppressor protein is vital for genomic stability, regulating cell cycle arrest, senescence, and apoptosis in response to DNA damage.
  • Mutations in the TP53 gene are frequent in cancer, highlighting p53's critical role as the "guardian of the genome."
  • A significant body of research exists on p53's function in cancer, necessitating a centralized resource.

Purpose of the Study:

  • To create a comprehensive, user-friendly knowledgebase for p53-related information.
  • To facilitate knowledge discovery and research by integrating and curating data on p53.
  • To provide researchers with accessible tools for analyzing p53 information.

Main Methods:

  • Initiation of the p53 knowledgebase project (http://p53.bii.a-star.edu.sg).
  • Development of a web portal with visualization and analysis tools.
  • Integration of published literature data with manually curated information.

Main Results:

  • The p53 knowledgebase is a user-friendly portal for accessing curated p53 data.
  • It includes information on p53 sequence, structure, mutations, polymorphisms, interactions, targets, and modifications.
  • The portal facilitates knowledge discovery through integrated data and analysis tools.

Conclusions:

  • The p53 knowledgebase centralizes critical data for researchers studying p53 and cancer.
  • This resource aims to accelerate research by providing easy access to comprehensive p53 information.
  • The project supports the scientific community by maintaining and presenting all relevant p53 data.

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