Improved pharmacological properties for superoxide dismutase modified with beta-cyclodextrin-carboxymethylcellulose polymer
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Updated: Jul 20, 2026

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Aymara Valdivia1, Yunel Pérez, Hector Ramírez
1Center for Enzyme Technology, University of Matanzas, Autopista a Varadero Km. 3.5, Matanzas, C.P. 44740, Cuba.
Abstract:
Superoxide dismutase was glycosidated with cyclodextrin-branched carboxymethylcellulose. The modified enzyme contained 1.4 mol polymer per mol protein and retained 87% of the initial activity. The anti-inflammatory activity of superoxide dismutase was 2.2-times increased after conjugation and its plasma half-life time was prolonged from 4.8 min to 7.2 h.
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