Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diffusional kurtosis imaging in the lung using hyperpolarized 3He.

Robert Trampel1, Jens H Jensen, Ray F Lee

  • 1Department of Radiology, New York University School of Medicine, New York, New York 10016-3240, USA.

Magnetic Resonance in Medicine
|September 8, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ComBat-Predict Enhances Generalizability of Neuroimaging Models to New Sites.

Human brain mapping·2026
Same author

Monte Carlo Assessment of Accuracy for Mean Kärger Model Water Exchange Rate Estimates From Diffusional Kurtosis Time Dependence.

NMR in biomedicine·2026
Same author

Population coding for visual and auditory quantity in human numerotopic maps.

Communications biology·2026
Same author

Decoding of columnar-level organization across cortical depth using BOLD- and CBV-fMRI at 7 T.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

Calibration of MRI-based reference intervals to new samples.

bioRxiv : the preprint server for biology·2025
Same author

Neonatal encephalopathy: a diffusional kurtosis imaging analysis of white matter to assess injury severity and recovery.

Pediatric research·2025
Same journal

Suppression of Oscillation and Ghosting in RF-Spoiled Gradient-Echo-Based Dynamic Imaging.

Magnetic resonance in medicine·2026
Same journal

A Simple, Dynamic Geometric Phantom for MRI and CT Reconstruction Pipelines: Beyond Shepp-Logan.

Magnetic resonance in medicine·2026
Same journal

7T 3D-EPI PCASL With High SNR Efficiency and Robustness to Through-Plane B<sub>0</sub> Field Gradients.

Magnetic resonance in medicine·2026
Same journal

A Comparison of Tissue Property Values Estimated Using Conventional Cardiac MRF and MT-Cardiac MRF.

Magnetic resonance in medicine·2026
Same journal

Dependence of the Extra-Cellular Diffusion Coefficient on the Fractions of Neurites and Cell Bodies in Gray Matter.

Magnetic resonance in medicine·2026
Same journal

Triple-Pulse <sup>23</sup>Na MRI Sequence (TriNa) for Simultaneous Acquisition of Spin-Density-Weighted and Fluid-Attenuated Images.

Magnetic resonance in medicine·2026
See all related articles

Diffusional kurtosis imaging (DKI) offers a novel approach to lung MRI, detecting small airway diseases. This advanced technique shows promise where conventional diffusion imaging falls short.

Area of Science:

  • Pulmonary Medicine
  • Radiology
  • Medical Imaging

Background:

  • Diseases affecting small lung airspaces are a growing health concern.
  • Conventional diffusion MRI has limitations in assessing small airway structures due to short diffusion distances.
  • Asthma and COPD involve small airway and alveolar abnormalities.

Purpose of the Study:

  • To introduce diffusional kurtosis imaging (DKI) as a novel MRI method.
  • To investigate DKI's sensitivity to longer diffusion distances in the lungs.
  • To evaluate DKI's potential for detecting small airway diseases.

Main Methods:

  • Development and application of diffusional kurtosis imaging (DKI).
  • Acquisition of preliminary DKI measurements in healthy subjects and a patient with suspected small airway disease.

Related Experiment Videos

  • Comparison of DKI metrics with conventional diffusion imaging parameters like apparent diffusion coefficient (ADC).

    • Main Results:

    • DKI is sensitive to diffusion over longer distances, potentially improving assessment of bronchi and bronchioles.
    • In a patient with suspected small airway disease, apparent diffusion coefficient (ADC) was similar to controls.
    • Diffusional kurtosis was markedly reduced in the patient compared to healthy controls, indicating potential abnormalities.

    Conclusions:

    • Diffusional kurtosis imaging (DKI) shows promise for assessing diseases of the small airways.
    • DKI may be more sensitive than conventional diffusion imaging for detecting subtle changes in bronchioles and bronchi.
    • This novel MRI technique could enhance the diagnosis and monitoring of small airway diseases.