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Updated: Jul 20, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Benefit design and specialty drug use
Dana P Goldman1, Geoffrey F Joyce, Grant Lawless
1Health Economics at RAND in Santa Monica, California, USA. dgoldman@rand.org
Patients with cancer, kidney disease, rheumatoid arthritis, and multiple sclerosis using specialty drugs face high out-of-pocket costs. Specialty drug use is insensitive to cost sharing, suggesting coverage should not be limited once patients who will benefit are identified.
Area of Science:
- Health economics
- Pharmaceutical policy
- Patient financial risk
Background:
- Privately insured patients with chronic conditions like cancer, kidney disease, rheumatoid arthritis, and multiple sclerosis often require expensive specialty drugs.
- Employer-sponsored health insurance does not always shield these patients from significant out-of-pocket healthcare expenditures.
- The cost-effectiveness and accessibility of specialty drugs remain critical concerns in healthcare management.
Purpose of the Study:
- To analyze patient spending on specialty drugs for four specific chronic conditions.
- To evaluate the impact of cost-sharing on the utilization of specialty drugs.
- To inform healthcare policy regarding coverage and management of high-cost specialty medications.
Main Methods:
- Examination of healthcare spending data for privately insured patients.
- Analysis of patient out-of-pocket expenses for cancer, kidney disease, rheumatoid arthritis, and multiple sclerosis treatments.
- Calculation of price elasticities to determine cost sensitivity of specialty drug use.
Main Results:
- Specialty drug utilization demonstrated low price elasticity, ranging from 0.01 to 0.21, indicating insensitivity to cost-sharing.
- Patients with these conditions, even with insurance, are at substantial risk for high out-of-pocket spending.
- Cost-sharing appears to be an ineffective mechanism for controlling specialty drug use.
Conclusions:
- Care management strategies should prioritize ensuring that patients who will gain the most benefit from specialty drugs receive them.
- Limiting coverage for specialty drugs, once patient benefit is established, is economically inefficient.
- Policy considerations should focus on value-based access rather than restrictive cost-sharing for essential specialty medications.
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