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Updated: Jul 20, 2026
05:51
A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
No association between the CNTF null mutation and schizophrenia or personality
Jun Nishiyama1, Mamoru Tochigi, Shin Itoh
1Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Psychiatric Genetics
|September 14, 2006
Summary
This study found no link between the ciliary neurotrophic factor (CNTF) gene mutation and schizophrenia in Japanese individuals. The CNTF gene mutation was also not associated with personality traits in the general population.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Ciliary neurotrophic factor (CNTF) is crucial for neurodevelopment.
- The CNTF gene is a candidate locus for schizophrenia based on neurodevelopmental hypotheses.
- Previous studies on CNTF mutations and schizophrenia have yielded inconsistent results.
Purpose of the Study:
- To investigate the association between a CNTF gene null mutation and schizophrenia in a Japanese population.
- To examine the relationship between the CNTF gene mutation and personality traits in the general population.
Main Methods:
- Case-control study involving 222 Japanese patients with schizophrenia and 237 healthy controls.
- Personality traits were assessed using the Revised NEO Personality Inventory.
Main Results:
- No statistically significant association was found between the CNTF gene null mutation and schizophrenia.
- No association was observed between the CNTF gene mutation and personality traits.
Conclusions:
- The study did not find evidence to support the association of the CNTF gene with schizophrenia in the Japanese population.
- The CNTF gene mutation does not appear to be associated with personality traits in this cohort.
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