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Budd-Chiari syndrome

Michael A Zimmerman1, Andrew M Cameron, R Mark Ghobrial

  • 1Division of Liver and Pancreas Transplantation, Department of Surgery, The Pfleger Liver Institute, The Dumont-UCLA Transplant Center, The David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, USA.

Clinics in Liver Disease
|September 15, 2006
PubMed

Insights

Budd-Chiari syndrome (BCS) involves hepatic venous outflow occlusion due to anatomical issues or clotting disorders. Diagnosis and supportive care are key, with surgical shunting and liver transplantation offering viable treatment options.

Area of Science:

  • Hepatology
  • Vascular Medicine
  • Gastroenterology

Background:

  • Budd-Chiari syndrome (BCS) is characterized by hepatic venous outflow occlusion.
  • It encompasses anatomical abnormalities and hypercoagulable disorders.
  • Common symptoms include hepatomegaly, abdominal pain, and ascites.

Purpose of the Study:

  • To outline the diagnostic approach for Budd-Chiari syndrome.
  • To review supportive medical therapies for BCS.
  • To evaluate surgical shunting and liver transplantation as treatment options.

Main Methods:

  • Review of clinical manifestations.
  • Analysis of diagnostic strategies.
  • Evaluation of treatment data for surgical and transplant options.

Main Results:

  • Budd-Chiari syndrome presents with varied clinical signs.
  • Medical management focuses on supportive care.
  • Surgical shunting and liver transplantation show promise.

Conclusions:

  • Effective management of Budd-Chiari syndrome requires accurate diagnosis and tailored therapy.
  • Surgical interventions and liver transplantation are critical treatment modalities for BCS.
  • Further research can optimize outcomes for patients with hepatic venous outflow obstruction.

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