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[Giant condyloma with malignant degeneration: a case report]
Yasuhito Funahashi1, Osamu Kamihira, Akitoshi Fukatsu
1The Department of Urology, Komaki City Hospital.
Hinyokika Kiyo. Acta Urologica Japonica
|September 16, 2006
Summary
This case study highlights a rare instance of giant condyloma (a benign anal wart) undergoing malignant transformation into squamous cell carcinoma. Despite initial negative biopsies, the patient underwent surgery and radiation, showing no recurrence after 18 months.
Area of Science:
- Oncology
- Urology
- Dermatology
Background:
- Giant condyloma acuminatum (GCA) is a rare, aggressive form of human papillomavirus (HPV)-induced anogenital wart.
- Malignant degeneration of GCA into squamous cell carcinoma (SCC) is uncommon but carries significant implications.
- Accurate histopathological diagnosis can be challenging, especially in early stages.
Observation:
- A 56-year-old male presented with a year-long, antibiotic-resistant penile infection initially suspected to be penile cancer.
- Two initial penile biopsies revealed condyloma acuminatum without malignancy.
- Despite continued antibiotic therapy, the condition worsened, necessitating a total penectomy and urinary diversion.
Findings:
- Post-surgical pathological examination of the resected tissue confirmed both condyloma acuminatum and invasive squamous cell carcinoma.
- Cancer cells were identified on the cut surface of the surgical specimens.
- Adjuvant radiation therapy was administered following the surgery.
Implications:
- This case underscores the importance of vigilant monitoring and repeat biopsies in cases of persistent or worsening giant condyloma, even with initial benign diagnoses.
- It highlights the potential for malignant transformation in GCA, necessitating aggressive management including surgical resection and potentially adjuvant therapies.
- Early detection and comprehensive treatment are crucial for improving outcomes in patients with GCA and associated malignancies.
