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Published on: November 26, 2015
Therapeutic time window of methylprednisolone in acoustic injury
Keiji Tabuchi1, Hidekazu Murashita, Shuhei Sakai
1Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan. ktabuchi@md.tsukuba.ac.jp
Hypothesis:
This study aims to investigate the therapeutic time window of methylprednisolone in acoustic injury.
Background:
Although glucocorticoids have been widely used in the treatment of acoustic injury, the therapeutic time window of glucocorticoids in acoustic injury has never been examined.
Methods:
Mice were exposed to 4-kHz pure tone of 128-dB sound pressure level for 4 hours. Auditory brainstem response was examined before, immediately after, and 2 weeks after acoustic overexposure.
Results:
Methylprednisolone significantly improved the auditory brainstem response threshold shifts 2 weeks after acoustic overexposure when it was administered before or immediately after acoustic overexposure, but not when administered 3 hours after acoustic overexposure.
Conclusion:
The present findings suggest that methylprednisolone possesses protective effects against acoustic injury of the cochlea with a short therapeutic time window.
