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Updated: Jul 19, 2026
Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
Published on: September 21, 2021
Experimental model of hemorrhagic stroke: rabbit immunization with HL-60 promyelocytic cell differentiation factor
M V Gapon1, S M Dranitsyna, N I Minkevich
1Laboratory of Hormonal Regulation Proteins, M M Shemyakin and Yu A Ovchinnikov Institute of Organic Biochemistry, Russian Academy of Sciences.
Abstract:
Rabbits immunized with synthetic HLDF differentiation factor developed hemorrhagic stroke with thrombosis of small cerebral vessels and destruction of vascular endotheliocytes. The severity of stroke correlated with serum level of antibodies to differentiation factor. The role of different sites of HLDF molecule in the induction of clinical signs of hemorrhagic stroke was studied.
