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Published on: September 20, 2018

Aspergillosis: spectrum of disease, diagnosis, and treatment

Penelope D Barnes1, Kieren A Marr

  • 1Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Infectious Disease Clinics of North America
|September 21, 2006
PubMed

Insights

Aspergillus infections pose significant health risks, causing allergic reactions in healthy people and severe illness in immunocompromised individuals. This review covers Aspergillus-related diseases, diagnostic hurdles, and available treatments.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Immunology

Background:

  • Aspergillus species are common environmental fungi.
  • These fungi cause a spectrum of diseases, from allergies to invasive infections.
  • Infections are particularly severe in immunocompromised patients.

Purpose of the Study:

  • To review the diverse range of infections caused by Aspergillus species.
  • To highlight the diagnostic challenges associated with Aspergillus infections.
  • To discuss current therapeutic strategies for managing these infections.

Main Methods:

  • Literature review of Aspergillus-related diseases.
  • Analysis of diagnostic methodologies.
  • Summary of established and emerging treatment options.

Main Results:

  • Aspergillus can cause allergic bronchopulmonary aspergillosis, chronic pulmonary aspergillosis, and invasive aspergillosis.
  • Diagnosis is often complicated by non-specific symptoms and the need for specialized tests.
  • Treatment requires a combination of antifungal agents and management of underlying conditions.

Conclusions:

  • Aspergillus infections represent a significant global health burden.
  • Improved diagnostic tools and targeted therapies are crucial for better patient outcomes.
  • Multidisciplinary approaches are essential for managing complex Aspergillus cases.

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