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Updated: Aug 19, 2026

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
Published on: March 8, 2017
[Rheological therapeutic effects in diseases of the inner ear]
K Hörmann1, M Bernal Sprekelsen
1Departamento de O.R.L. Hospital General de Kaiserlautern/R.F.A.
Abstract:
The aim of the rheological treatment in sudden deafness is the improvement of the microcirculation in the inner ear by hemodilution and decreased viscosity of the blood. Both parameters have been checked in two groups of patients suffering from sudden deafness; one treated with Dextran-40 and Pentoxifylline, the other with Dextran-40 only. Improvement of rheological characteristics of blood was statistically significant in the combined therapy with Dextran-40 and Pentoxifylline. Two cohorts of sudden deafness patients--one selected, one non selected--treated with Pentoxifylline and Dextran 40 have been evaluated in respect of hearing improvement under this rheological results compared with the spontaneous remission rate given by Weinaug in 1984.
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