Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elevated complement C3 is associated with early restenosis after eversion carotid endarterectomy.

Gábor Széplaki1, Lilian Varga, Judit Laki

  • 13rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.

Thrombosis and Haemostasis
|September 28, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stress and passion predict burnout in regular exercisers.

Frontiers in sports and active living·2026
Same author

Pulsed Field Ablation With a Variable Loop Circular Catheter in Atrial Fibrillation: Acute Outcomes From the VARIPURE Multicenter Study.

Heart rhythm·2026
Same author

Studying exercise-induced affect in older adults: how the circumplex model could enhance theoretical and practical advances in the field.

Frontiers in aging·2026
Same author

Primitive reflexes as candidate quantitative readouts of hierarchical inhibitory control across the lifespan.

Frontiers in human neuroscience·2026
Same author

Cultural and Sex-Related Differences in Free-Word Associations with "Sweets": A Multinational Online Study.

Nutrients·2026
Same author

From social media to body image distress: Problematic internet use, exercise addiction, and enhancement drugs use across countries.

Journal of behavioral addictions·2026

High C3 complement levels are linked to increased restenosis risk after carotid endarterectomy (CEA), particularly in MBL2 A/A gene carriers. This suggests C3 plays a role in post-CEA inflammation and restenosis development.

Area of Science:

  • Vascular surgery
  • Immunology
  • Genetics

Background:

  • Early restenosis after carotid endarterectomy (CEA) involves inflammation and smooth muscle cell hyperplasia.
  • Mannose-binding lectin (MBL2) gene polymorphisms influence restenosis risk, especially in homozygous normal (A) allele carriers.
  • Complement component 3 (C3) and acute-phase reactants (APRs) are inflammatory markers, but their role in post-CEA restenosis is unclear.

Purpose of the Study:

  • To investigate the association between C3 levels and early restenosis following CEA.
  • To examine the relationship between non-complement APRs (CRP, haptoglobin, alpha2HSglycoprotein) and early restenosis.
  • To determine if MBL2 genotype influences C3 levels and restenosis risk.

Main Methods:

  • Radial immunodiffusion or immunoturbidimetry measured APRs in 64 patients post-eversion CEA.

Related Experiment Videos

  • Carotid duplex scans (CDS) monitored restenosis for at least one year.
  • Polymerase chain reaction sequence-specific priming (PCR-SSP) determined MBL2 genotypes.

    • Main Results:

    • C3 levels increased during follow-up and correlated with restenosis percentage in MBL2 A/A carriers.
    • High C3 levels were associated with nearly five-fold increased odds of significant restenosis (>50% diameter reduction), independent of MBL2 genotype, age, and gender.
    • No significant associations were found between non-complement APRs and early restenosis.

    Conclusions:

    • C3 is associated with early restenosis after CEA and may play a direct role in its development.
    • The observed association between C3 and restenosis is partially linked to an intact MBL lectin pathway.
    • C3 regulation differs from non-complement APRs, suggesting potential clinical utility in monitoring C3 levels post-CEA.