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Prostatic-type epithelium in urinary bladder. Clinical, histologic, and immunohistochemical study
J Delladetsima1, C Theodorou, Y Dapolla
1Pathology Department, University of Athens, Laiko Hospital, Greece.
Urology
|November 1, 1990
Summary
Prostate-type epithelium in the urinary bladder, identified through clinical and immunohistochemical analysis, suggests metaplasia. This finding was observed in six male patients presenting with painless hematuria.
Area of Science:
- Uropathology
- Surgical Pathology
- Oncology
Background:
- Urinary bladder mucosa typically exhibits transitional epithelium.
- Prostate-type epithelium in the bladder is an uncommon finding.
- Understanding its characteristics is crucial for accurate diagnosis.
Purpose of the Study:
- To investigate the clinical, morphological, and immunohistochemical features of urinary bladder mucosa with prostate-type epithelium.
- To determine the histogenetic origin of these lesions.
Main Methods:
- Clinical case review of six male patients.
- Histopathological examination of bladder tissue.
- Immunohistochemical analysis using prostatic specific antigen and prostatic acid phosphatase markers.
Main Results:
- Observed two lesion types: polypoid and flat.
- Both types showed prostatic-type and transitional surface epithelium.
- Polypoid lesions featured prominent prostatic-type glands.
- Immunohistochemistry confirmed prostatic markers.
Conclusions:
- The presence of prostatic-type epithelium in the bladder is likely due to metaplasia.
- Painless hematuria was a common presenting symptom.
- Further research may elucidate the clinical significance and management of this condition.