Convergent inputs to the inferior olive from the dorsal column nuclei and pretectum in the cat

The dorsal column nuclei (DCN) consist of an anatomically heterogeneous population of neurons, some of which project to the inferior olive and pretectum. Recent anatomical experiments on cats have shown that neurons in the parts of the pretectum which receive input from DCN also project to the inferior olive. Thus, DCN neurons provide an input to the inferior olive via both a direct DCN-olivary pathway and an indirect pathway through the pretectum. This connective situation provides a mechanism by which incoming somatic sensory information that is processed at different levels of the brainstem (i.e. DCN and pretectum) has access to the cerebellum by way of the inferior olive. It is of interest whether the two sets of differently processed information are conveyed to the same group of inferior olive neurons. Although DCN and pretectal projections to the inferior olive have been generally described, the relationship between the DCN targets in the inferior olive and those specifically from the DCN-recipient parts of the pretectum have not. To address this question, this study used single and double anterograde labeling strategies with a variety of tracers to compare the two targets in the inferior olive of cats. It was found that projections to the inferior olive from the DCN-recipient parts of the pretectum were located predominantly in the dorsal accessory portion of the inferior olive where they overlapped extensively with projections directly from DCN. These results provide evidence for a pathway by which sequentially processed somatic sensory information, first in the DCN and then in the pretectum, has access to the cerebellum by way of the same group of inferior olive neurons.