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Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
Published on: November 19, 2014
The schizophrenic faces of PICK1
Kumlesh K Dev1, Jeremy M Henley
1Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma, WSJ 386-7-43, Lichtstrasse 35, CH-4056 Basel, Switzerland. kumlesh_k.dev@novartis.com
Abstract:
Schizophrenia is a grave psychiatric disorder with psychotic symptoms and an enigmatic etiology. Family studies have strongly indicated that genetic risk factors have a role in this disease. Recent findings, together with previously established evidence, highlight the PDZ-domain-containing protein interacting with C-kinase 1 (PICK1) as a promising candidate for a schizophrenia susceptibility gene. Here, we outline possible molecular mechanisms, discuss clinical case-studies that indicate an unexpected role of PICK1 in schizophrenia and discuss potential avenues for pharmacological manipulation of PICK1.
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