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Related Concept Videos

Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...
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The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...
Personality Disorders: Paranoid and Schizoid01:22

Personality Disorders: Paranoid and Schizoid

Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
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Drug Therapy01:28

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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
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Schizophrenia01:17

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Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
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Related Experiment Video

Updated: Jul 19, 2026

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
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The schizophrenic faces of PICK1.

Kumlesh K Dev1, Jeremy M Henley

  • 1Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma, WSJ 386-7-43, Lichtstrasse 35, CH-4056 Basel, Switzerland. kumlesh_k.dev@novartis.com

Trends in Pharmacological Sciences
|October 3, 2006
PubMed
Summary

Genetic factors contribute to schizophrenia, a severe psychiatric disorder. The protein interacting with C-kinase 1 (PICK1) is a potential susceptibility gene, with possible molecular mechanisms and therapeutic targets being explored.

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Last Updated: Jul 19, 2026

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
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Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Schizophrenia is a complex psychiatric disorder with a significant genetic component.
  • Identifying genetic risk factors is crucial for understanding schizophrenia etiology.
  • The PDZ-domain-containing protein interacting with C-kinase 1 (PICK1) has emerged as a potential candidate gene.

Purpose of the Study:

  • To explore the role of PICK1 in schizophrenia.
  • To investigate potential molecular mechanisms underlying PICK1's involvement.
  • To discuss clinical implications and pharmacological targeting of PICK1.

Main Methods:

  • Review of existing genetic and molecular findings related to PICK1 and schizophrenia.
  • Analysis of clinical case studies.
  • Exploration of potential therapeutic strategies targeting PICK1.

Main Results:

  • Evidence suggests PICK1 plays a role in schizophrenia susceptibility.
  • Potential molecular pathways involving PICK1 are identified.
  • Clinical observations indicate an unexpected involvement of PICK1.

Conclusions:

  • PICK1 is a promising candidate gene for schizophrenia.
  • Further research into PICK1's molecular functions is warranted.
  • Pharmacological modulation of PICK1 may offer novel therapeutic avenues for schizophrenia.