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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Adrenergic Agonists: Therapeutic Uses01:30

Adrenergic Agonists: Therapeutic Uses

Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and anaphylaxis:...
Allergic Reactions02:06

Allergic Reactions

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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
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Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
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Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
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Anaesthesia for the allergic patient.

H Bouaziz1, M C Laxenaire

  • 1Service d'Anesthésie-Réanimation, Centre Hospitalier Universitaire de Nancy, Hôpital Central, Nancy, France.

Current Opinion in Anaesthesiology
|October 3, 2006
PubMed
Summary

Patients with known allergies to muscle relaxants or latex require special attention during pre-anesthetic evaluations. Other allergies, like to antibiotics or local anesthetics, are less likely to cause severe anesthetic reactions.

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Area of Science:

  • Anesthesiology
  • Immunology

Background:

  • Anesthesia-induced allergic reactions are primarily linked to muscle relaxants and latex.
  • Identifying patients at risk is crucial for preventing anaphylaxis during surgery.

Purpose of the Study:

  • To identify patient populations at higher risk for allergic reactions during anesthesia.
  • To clarify the role of various allergies in the development of anesthetic anaphylaxis.

Main Methods:

  • Review of existing literature on anesthetic allergies.
  • Analysis of pre-anesthetic evaluation protocols.
  • Case study review of anaphylactic shock during anesthesia.

Main Results:

  • Patients with pre-existing allergies to muscle relaxants or latex are at increased risk.
  • Allergies to antibiotics or other drugs do not appear to increase the risk of anaphylaxis from anesthetic agents.
  • Allergy to local anesthetics is rare and can often be ruled out with challenge testing.

Conclusions:

  • Pre-anesthetic screening should prioritize patients with known sensitivities to muscle relaxants and latex.
  • Non-anesthetic drug allergies have a low predictive value for anesthetic-induced anaphylaxis.
  • Careful patient selection and targeted allergy testing can mitigate anesthetic risks.