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Recurrent benign lymphocytic meningitis.

Marwan Shalabi¹, Richard J Whitley

¹Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America

|October 10, 2006

Summary

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Recurrent benign lymphocytic meningitis, often caused by herpes simplex virus type 2, presents with painful aseptic meningitis and temporary neurological issues. Antiviral medications may help manage symptoms and prevent future occurrences.

Area of Science:

Neurology
Infectious Diseases
Virology

Background:

Recurrent benign lymphocytic meningitis is a painful, aseptic meningitis syndrome.
It is often associated with transient neurological symptoms.
Herpes simplex virus type 2 is a common causative agent.

Purpose of the Study:

To review the characteristics of recurrent benign lymphocytic meningitis.
To discuss diagnostic methods, including polymerase chain reaction for viral DNA detection.
To explore therapeutic options, including antiviral medications.

Main Methods:

Literature review of recurrent benign lymphocytic meningitis cases.
Analysis of diagnostic techniques for herpes simplex virus type 2.
Evaluation of antiviral treatments like acyclovir, valacyclovir, and famciclovir.

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Main Results:

Herpes simplex virus type 2 is frequently identified as the cause.
Polymerase chain reaction is a key diagnostic tool.
Antiviral therapies are used for episodic treatment and suppression, though evidence is limited.

Conclusions:

Recurrent benign lymphocytic meningitis is typically self-limiting.
Antiviral therapy is considered potentially beneficial but lacks robust clinical trial data.
Further research is needed to establish the efficacy and safety of antiviral treatments.