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Updated: Jul 19, 2026

Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation
Published on: August 13, 2015
Inflammatory disorders of the prostate and the distal genital tract
Jill E Langer1, François Cornud
1Department of Radiology, Hospital of the University of Pennsylvania, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA. jill.langer@uphs.upenn.edu
Abstract:
Inflammatory disease of the prostate and distal genital tract is emerging as a major health problem because it is estimated that up to 15% of adult men may be affected at some point in their lives. Clinically, the diagnosis of "prostatitis" refers to multiple disorders that cause pelvic pain and discomfort, ranging from acute bacterial infection to complex conditions that may not necessarily be caused by prostatic inflammation. Because the traditional etiology-based classification system did not always correlate with symptoms and therapeutic efficacy, a new classification of prostatitis has been suggested by the National Institutes of Health. New imaging techniques such as high-resolution transrectal ultrasonography (TRUS) and MR imaging provide exquisite anatomic detail and often play a crucial role in the evaluation of these patients.
Insights
Prostatitis affects up to 15% of adult men, encompassing various pelvic pain disorders. A new National Institutes of Health classification and advanced imaging like transrectal ultrasonography (TRUS) aid diagnosis and treatment.
Area of Science:
- Urology
- Andrology
- Medical Imaging
Background:
- Prostatitis, an inflammatory condition of the prostate and distal genital tract, affects up to 15% of adult men.
- The clinical diagnosis of prostatitis encompasses diverse disorders causing pelvic pain, not solely limited to prostatic inflammation.
- Traditional classification systems often lack correlation with symptoms and treatment effectiveness.
Purpose of the Study:
- To introduce the National Institutes of Health (NIH) revised classification for prostatitis.
- To highlight the role of advanced imaging in evaluating prostatitis patients.
Main Methods:
- Review of the NIH's new prostatitis classification system.
- Discussion of advanced imaging modalities including high-resolution transrectal ultrasonography (TRUS) and MR imaging.
Main Results:
- The NIH classification offers a more relevant framework compared to traditional etiological approaches.
- High-resolution TRUS and MR imaging provide detailed anatomical information crucial for diagnosis.
Conclusions:
- The revised NIH classification addresses limitations of older systems.
- Advanced imaging techniques are essential tools for the accurate evaluation and management of prostatitis.
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