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Updated: Jul 19, 2026
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Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Cyberknife radiosurgery for basal skull plasmacytoma
Eric T Wong1, Xing-Qi Lu, Janakiram Devulapalli
1Brain Tumor Center and Neuro-Oncology Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA. ewong@bidmc.harvard.edu
Summary
CyberKnife radiosurgery successfully treated a rare medullary plasmacytoma in the clivus. This frameless, image-guided approach resulted in a complete radiographic response with no acute toxicity, offering a new treatment option.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Medullary plasmacytomas are rare tumors affecting the clivus and foramen magnum.
- Stereotactic radiosurgery offers a minimally invasive treatment option for complex tumors.
- CyberKnife is an advanced frameless, image-guided radiosurgery system.
Observation:
- A patient with a clival medullary plasmacytoma extending into the foramen magnum was treated with CyberKnife radiosurgery.
- The treatment was delivered using frameless, image-guided stereotactic radiosurgery.
- No acute toxicity was observed during or within 24 hours post-treatment.
Findings:
- The patient achieved a complete and durable radiographic response on MRI 12+ months after CyberKnife treatment.
- This represents the first reported case of successful CyberKnife radiosurgery for a medullary plasmacytoma.
- The treatment was well-tolerated with no immediate adverse effects.
Implications:
- CyberKnife radiosurgery is a viable and effective treatment for medullary plasmacytomas in challenging locations.
- This approach may offer a less invasive alternative to traditional surgery for such tumors.
- Further research is warranted to explore the broader application of CyberKnife for rare skull base tumors.
