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Published on: September 13, 2018
The analytical approach to polydimethylsiloxane microfluidic technology and its biological applications
Emil P Kartalov1, W French Anderson, Axel Scherer
1Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Norris Cancer Center, NOR6346, 1441 Eastlake Avenue, Los Angeles, California 90033, USA.
This review covers polydimethylsiloxane (PDMS) microfluidic devices and their use in biology. It classifies existing devices, compares microfluidics and biology scales, and analyzes applications for future insights.
Area of Science:
- Biotechnology
- Materials Science
- Microfluidics
Background:
- Polydimethylsiloxane (PDMS) is a widely used material for microfluidic devices.
- Microfluidics offers advantages for biological applications due to small sample volumes and precise control.
Purpose of the Study:
- To review and classify existing PDMS microfluidic devices based on technology and biological applications.
- To compare the capabilities of PDMS microfluidics with standard biological methods.
- To provide insights for the future development of PDMS microfluidic devices.
Main Methods:
- Classification of PDMS microfluidic devices into single-layer, multilayer, and integrated types.
- Analysis of surface chemistry modifications for PDMS devices.
- Comparison of microfluidic and biological scales.
- Reclassification of devices based on biological applications.
Main Results:
- A logical framework for classifying PDMS microfluidic devices is presented.
- The promise and limitations of PDMS microfluidics in biological contexts are identified.
- Existing devices are re-derived and compared within the proposed framework.
Conclusions:
- PDMS microfluidic devices show significant potential for various biological applications.
- Understanding the scale compatibility and limitations is crucial for effective design.
- This review offers a roadmap for future advancements in PDMS microfluidics for cell and molecular biology.
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