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Taste comparison of corticosteroid suspensions
Thomas D Regan1, Dawn Lewis, Scott A Norton
1Dermatology Department, Naval Medical Center San Diego, San Diego, CA 92134-2098, USA. Thomas.Regan2@us.army.mil
Journal of Drugs in Dermatology : JDD
|October 17, 2006
Summary
This study compared the palatability of eight corticosteroid suspensions. Some corticosteroid suspensions had significantly better tastes, potentially improving pediatric patient compliance.
Area of Science:
- Pharmacology
- Pediatric Medicine
- Clinical Pharmacy
Background:
- Palatability of antibiotic suspensions is well-studied, but less is known about corticosteroid suspensions.
- Improving medication taste is crucial for patient adherence, especially in pediatric populations.
Purpose of the Study:
- To compare the palatability of eight commonly prescribed liquid corticosteroid suspensions.
- To provide data to guide clinical prescribing practices and enhance patient compliance.
Main Methods:
- A randomized, double-blind study involving 31 adult volunteers.
- Volunteers tasted and rated eight pediatric corticosteroid suspensions for taste and aftertaste.
- Mean palatability scores were statistically compared.
Main Results:
- Corticosteroid suspensions were categorized into two palatability groups.
- Higher palatability scores were observed for Orapred, Pediapred, and a dexamethasone suspension.
- Lower palatability scores were noted for a prednisone suspension and four cherry-flavored prednisolone suspensions.
Conclusions:
- Significant differences in palatability exist among corticosteroid suspensions.
- This information can aid clinicians in selecting preferred corticosteroid formulations.
- Improved taste may lead to better compliance in children.
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