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[Hyperhomocysteinaemia and type 2 diabetes].
E Vangelder1, F Delecourt, M-B Cardozo
1Laboratoire de Biochimie, Hôpital Saint Philibert, Lomme. Vangelder.Elisabeth@ghicl.net
Annales De Biologie Clinique
|October 17, 2006
Summary
Elevated homocysteine levels are a significant risk factor for cardiovascular events in individuals with type 2 diabetes. This finding highlights the importance of monitoring homocysteine for cardiovascular risk assessment in diabetic patients.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Nephrology
Background:
- Hyperhomocysteinemia is a known risk factor for cardiovascular events in non-diabetic populations.
- The role of hyperhomocysteinemia in cardiovascular event development among patients with type 2 diabetes requires further investigation.
Purpose of the Study:
- To investigate the association between hyperhomocysteinemia and cardiovascular events in patients diagnosed with type 2 diabetes.
Main Methods:
- A cohort of 185 patients with type 2 diabetes was consecutively enrolled.
- Measurements included homocysteine, creatinine, cholesterol, triglyceride levels, and HbA1c.
- Cardiovascular events (myocardial infarction, peripheral arteriopathy, cerebrovascular accident) were recorded for 121 patients.
Main Results:
- Patients experiencing cardiovascular events were older and had higher homocysteine and creatinine concentrations.
- Adjusted plasma homocysteine levels were significantly higher in patients with cardiovascular events (15.4 ± 3.52 µmol/L) compared to those without (13.13 ± 2.26 µmol/L; p = 2 x 10⁻⁵).
Conclusions:
- Hyperhomocysteinemia is an independent risk factor for cardiovascular events in patients with type 2 diabetes.
- This association remains significant even after adjusting for age and renal function.
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