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Outer-Boundary Assisted Segmentation and Quantification of Trabecular Bones by an Imagej Plugin
Published on: March 14, 2018
Autocalibrating parallel imaging of in vivo trabecular bone microarchitecture at 3 Tesla
S Banerjee1, S Choudhury, E T Han
1Department of Radiology, University of California-San Francisco, San Francisco, California 94158, USA. banerjee@mrsc.ucsf.edu
Magnetic Resonance in Medicine
|October 17, 2006
Summary
Generalized Autocalibrating Partially Parallel Acquisition (GRAPPA) with modified reconstruction enables high-resolution MRI of trabecular bone. This technique preserves image quality and enhances signal-to-noise ratio efficiency for osteoporosis assessment.
Area of Science:
- Biomedical Imaging
- Bone Microarchitecture Analysis
- Magnetic Resonance Imaging Physics
Background:
- Trabecular bone microarchitecture is crucial for skeletal health, with deterioration linked to osteoporosis.
- High-resolution MRI (HR-MRI) offers noninvasive assessment of bone structure but suffers from long acquisition times.
- Partially parallel imaging (PPI) techniques can accelerate MRI acquisition, improving efficiency and flexibility.
Purpose of the Study:
- To implement and evaluate the Generalized Autocalibrating Partially Parallel Acquisition (GRAPPA) technique with modified reconstruction for in vivo HR-MRI of trabecular bone.
- To assess the impact of GRAPPA-based reconstruction on image quality and trabecular bone structural parameter measurements.
- To investigate the potential of PPI for enhancing the signal-to-noise ratio (SNR) efficiency in multiple-acquisition balanced steady-state free precession (b-SSFP) sequences.
Main Methods:
- Implementation of GRAPPA technique with modified reconstruction for HR-MRI.
- Application to in vivo imaging of trabecular bone microarchitecture using a multiple-acquisition b-SSFP sequence at 3 Tesla.
- Evaluation of image characteristics and trabecular bone structural parameters with GRAPPA-based reconstruction.
Main Results:
- Image quality and depiction of trabecular microstructures were preserved using GRAPPA-based reconstruction.
- The feasibility of employing PPI for HR-MRI of trabecular bone was demonstrated.
- GRAPPA-based PPI showed potential for increasing SNR efficiency in b-SSFP imaging protocols.
Conclusions:
- Modified GRAPPA reconstruction is a feasible technique for accelerated in vivo HR-MRI of trabecular bone microarchitecture.
- PPI using GRAPPA can maintain image quality while reducing acquisition time, aiding osteoporosis assessment.
- The study highlights the potential of PPI to improve SNR efficiency in b-SSFP sequences for bone imaging.
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