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Updated: Jul 19, 2026
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A Single Cell Dissociation Approach for Molecular Analysis of Urinary Bladder in the Mouse Following Spinal Cord Injury
Published on: June 17, 2020
Spinal-injured neuropathic bladder antisepsis (SINBA) trial
1Spinal Medicine Department, Prince of Wales Hospital, Sydney, New South Wales, Australia.
Spinal Cord
|October 18, 2006
Summary
Methenamine hippurate (MH) and cranberry tablets do not prevent urinary tract infections (UTIs) in individuals with spinal cord injury (SCI)-related neuropathic bladder. This study found no significant benefit over placebo for either intervention in preventing UTIs.
Area of Science:
- Urology
- Neurology
- Infectious Diseases
Background:
- Urinary tract infections (UTIs) are a common complication for individuals with neuropathic bladder secondary to spinal cord injury (SCI).
- Preventive strategies are crucial to reduce UTI incidence and associated morbidity in this vulnerable population.
Purpose of the Study:
- To evaluate the efficacy of Methenamine Hippurate (MH) in preventing UTIs in patients with SCI-induced neuropathic bladder.
- To assess the effectiveness of cranberry tablets as a prophylactic measure against UTIs in individuals with SCI and neurogenic bladder.
Main Methods:
- A double-blind, factorial-design randomized controlled trial (RCT) was conducted.
- 305 participants with SCI and neurogenic bladder were randomized to receive either Methenamine Hippurate (1g twice-daily), cranberry tablets (800mg twice-daily), or placebo.
- The primary outcome was the time to the first symptomatic UTI, with a 6-month follow-up period.
Main Results:
- Multivariate analysis showed no statistically significant difference in UTI-free period for patients receiving Methenamine Hippurate compared to placebo (HR 0.96, P=0.75).
- Similarly, patients randomized to cranberry tablets did not experience a significantly longer UTI-free period than those on placebo (HR 0.93, P=0.70).
Conclusions:
- Neither Methenamine Hippurate nor cranberry tablets demonstrate a benefit in preventing symptomatic UTIs in patients with neuropathic bladder following SCI.
- Current standard regimens for managing neuropathic bladder in SCI patients do not appear to be enhanced by the addition of MH or cranberry for UTI prevention.
