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[The daily dynamics of blood lipids in elderly subjects with hypertension]
Insights
Elderly patients with hypertension show elevated blood lipids and daytime acrophases for atherogenic fractions. These circadian rhythm changes may increase complication risks, suggesting tailored chronotherapy approaches.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Chronobiology
Context:
- Elderly individuals with sclerotic systolic hypertension (SSH) and essential hypertension (EH) exhibit distinct lipid profiles compared to normal subjects.
- Hypertension is associated with significant alterations in lipid metabolism and circadian rhythms.
Purpose:
- To investigate the differences in lipid profiles and circadian rhythmicity of lipid fractions between hypertensive elderly patients and normal subjects.
- To identify potential atherogenic shifts in lipid transport systems in elderly patients with SSH and EH.
Summary:
- Patients with SSH and EH displayed higher levels of total lipids, cholesterol, triglycerides, lipoproteins, phospholipids, and nonesterified fatty acids than normal subjects.
- Atherogenic lipid fractions (cholesterol, triglycerides, low and very low density lipoproteins) showed synchronized daytime acrophases (2-4 p.m.) in hypertensive patients, unlike normal subjects.
- Divergent circadian changes in lipid fractions may disrupt other metabolic processes and blood coagulation, potentially leading to complications.
Impact:
- Findings highlight the importance of circadian variations in lipid metabolism for hypertensive patients.
- Suggests the need for developing chronotherapeutic strategies for managing hypertension-related lipid disorders.
- Recommends assessing lipid metabolism parameters between 2-4 p.m. to detect latent atherogenic shifts in elderly hypertensive patients.
Abstract:
Three groups of elderly subjects were examined: patients with sclerotic systolic hypertension (SSH), with essential hypertension (EH), and normal subjects. The blood levels of total lipids, cholesterol, triglycerides, low and very low density lipoproteins, phospholipids, and nonesterified fatty acids were significantly higher in the patients than in normal subjects. In contrast to those in normal subjects, acrophases of atherogenic lipid fractions (cholesterol, triglycerides, low and very low density lipoproteins) in the patients were synchronized and occurred in the day time (at 2-4 p.m.). Diverse directions of circadian changes in lipid fractions in the patients and normal subjects may contribute to alteration in the rhythmicity of other metabolisms and in the blood coagulation system, thus leading to various complications. This fact necessitates development of methodologic approaches to chronotherapy of the afore-said disorders. To detect latent atherogenic shifts in the lipid transport system in elderly patients with SSH and EH, studies of lipid metabolism parameters are recommended to be carried out between 2 and 4 o'clock p.m.