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Usefulness of D-Dimers and fibrinogen plasma determination in patients with polyvascular disease

M Bosevski1, S Kostoska, S Tosev

  • 1Angiology Division, Institute for Cardiovascular Diseases, Skopje, Macedonia.

Angiologiia I Sosudistaia Khirurgiia = Angiology and Vascular Surgery
|October 21, 2006
PubMed

Insights

Fibrinogen and D-Dimers are key predictors of mortality in patients with both peripheral artery disease (PAD) and coronary artery disease (CAD). These biomarkers can help prognosticate outcomes in individuals with polyvascular disease.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Research
  • Vascular Disease

Background:

  • Peripheral artery disease (PAD) and coronary artery disease (CAD) often coexist, increasing patient mortality risk.
  • Prognosticating mortality in patients with polyvascular disease requires identification of reliable biomarkers.

Purpose of the Study:

  • To evaluate the prognostic value of plasma fibrinogen, D-Dimers, and antithrombin III levels for mortality in patients with coexistent PAD and CAD.

Main Methods:

  • A 36-month study enrolled 90 patients with PAD and CAD.
  • Evaluated parameters included clinical factors, vascular indices (ankle-brachial index), lipid profiles, and hemostatic markers (fibrinogen, D-Dimers, antithrombin III).
  • Linear and multivariate regression models were used to identify variables associated with cardiovascular events and mortality predictors.

Main Results:

  • Cardiovascular events correlated with fibrinogen (r=0.59) and D-Dimers (r=0.48).
  • Overall mortality was 8.89% over three years.
  • Independent predictors of mortality identified by multivariate analysis were fibrinogen (score 2.78), D-Dimers (score 17.24), and ankle-brachial index (score 4.84).

Conclusions:

  • Fibrinogen and D-Dimers are independent predictors of mortality in patients with polyvascular disease.
  • These hemostatic markers offer significant prognostic value for mortality risk stratification in patients with coexisting PAD and CAD.
Abstract

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