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Updated: Jul 8, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
MicroRNA signatures in human cancers
George A Calin1, Carlo M Croce
1Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA.
MicroRNA (miRNA) alterations drive human cancer development and progression. miRNA profiling in tumors reveals diagnostic and prognostic signatures, offering insights into cancer pathways and therapeutic targets.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- MicroRNA (miRNA) dysregulation is a key factor in human cancer initiation and progression.
- Differential miRNA expression in cancer cells stems from genomic location, epigenetic changes, and altered miRNA processing.
- miRNA expression profiling in tumors has revealed significant associations with various cancer aspects.
Purpose of the Study:
- To elucidate the role of miRNA alterations in human cancer.
- To explore the causes behind widespread differential miRNA expression in malignant cells.
- To highlight the utility of miRNA profiling in cancer diagnosis, staging, prognosis, and treatment response.
Main Methods:
- Analysis of miRNA gene locations within cancer-associated genomic regions.
- Investigation of epigenetic mechanisms influencing miRNA expression.
- Assessment of alterations in the miRNA processing machinery.
- Application of miRNA expression profiling on human tumor samples.
Main Results:
- Identified specific miRNA signatures in human tumors linked to diagnosis, staging, progression, and prognosis.
- Established connections between miRNA expression profiles and patient response to cancer treatments.
- Discovered miRNA genes acting as downstream targets of oncogenic pathways.
- Found miRNA genes that target protein-coding genes crucial for cancer development.
Conclusions:
- MicroRNA alterations are fundamental to human cancer.
- miRNA profiling is a valuable tool for cancer management and research.
- Understanding miRNA roles can lead to novel therapeutic strategies targeting oncogenic pathways.
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