Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

Bone Remodeling and Repair

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

In vivo rAAV-mediated human TGF-β overexpression reduces perifocal osteoarthritis and improves osteochondral repair in a large animal model at one year.

Osteoarthritis and cartilage·2022

Same author

Surgical therapy in osteoarthritis.

Osteoarthritis and cartilage·2022

Same author

Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.

European cells & materials·2021

Same author

'Actum ne agas'.

Osteoarthritis and cartilage·2021

Same author

[Zoster disease after Shingrix vaccination].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2020

Same author

Platelet-rich plasma (PRP) as therapy for cartilage, tendon and muscle damage - German working group position statement.

Journal of experimental orthopaedics·2020

Search research articles

Related Experiment Video

Updated: Jul 19, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

[Gene therapy in orthopaedic surgery].

H Madry¹, D Kohn, M Cucchiarini

¹Labor für Experimentelle Orthopädie Klinik für Orthopädie und Orthopädische Chirurgie, Universitätsklinikum des Saarlandes, 66421, Homburg, hmad@hotmail.com

|October 25, 2006

Summary

Gene therapy shows promise for orthopaedic surgery, aiding in the repair of cartilage and bone defects. Early clinical trials for rheumatoid arthritis demonstrate its feasibility and potential for novel molecular treatments.

More Related Videos

Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications

Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications

Published on: December 8, 2016

Related Experiment Videos

Last Updated: Jul 19, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications

Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications

Published on: December 8, 2016

Area of Science:

Orthopaedic surgery
Molecular biology
Regenerative medicine

Context:

Gene therapy research is advancing for genetic and non-Mendelian diseases in orthopaedics.
Challenges include gene vector selection, production, transfer technology, and efficacy evaluation.
Initial clinical studies for rheumatoid arthritis gene therapy confirm practical feasibility.

Purpose:

To explore the application and efficacy of gene therapy in orthopaedic surgery.
To highlight advancements in gene transfer and vector technologies for orthopaedic applications.
To assess the potential of gene-based treatments for cartilage and bone repair.

Summary:

Gene therapy is under intense investigation for orthopaedic conditions.
Experimental progress involves complex gene vector and transfer technologies.
Clinical studies indicate gene therapy's effectiveness in repairing articular cartilage and bone defects.

Impact:

Gene therapy offers a promising avenue for novel molecular treatments in orthopaedics.
Successful applications could revolutionize the management of orthopaedic diseases.
This field holds potential for significant advancements in patient care and surgical outcomes.