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[Cross-reacting Candida albicans antigens in the pathogenesis of candidiasis]
Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|October 1, 1990
Abstract:
Organ- and tissue-specific antigens with affinity to C. albicans have been detected in some organs and tissues of the body. The occurrence of C. albicans colonization of different organs correlates with the presence of cross-reacting antigens in these organs.
Insights
Candida albicans (C. albicans) antigens cross-react with human tissues. This cross-reactivity correlates with C. albicans colonization in various organs, suggesting a link between host antigens and fungal presence.
Area of Science:
- Immunology
- Microbiology
- Pathology
Background:
- Organ- and tissue-specific antigens have been identified in various human tissues.
- Candida albicans (C. albicans) is an opportunistic fungal pathogen that can colonize different organs.
Purpose of the Study:
- To investigate the presence of antigens in human organs and tissues that exhibit affinity for C. albicans.
- To determine if there is a correlation between C. albicans colonization and the presence of cross-reacting antigens.
Main Methods:
- Detection of organ- and tissue-specific antigens.
- Assessment of C. albicans colonization in various organs.
- Analysis of the correlation between antigen presence and fungal colonization.
Main Results:
- Organ- and tissue-specific antigens with affinity to C. albicans were detected in certain human organs and tissues.
- The presence of these cross-reacting antigens correlated with C. albicans colonization in the affected organs.
Conclusions:
- A link exists between host tissue antigens and C. albicans colonization.
- Cross-reacting antigens may play a role in the susceptibility or response to C. albicans infections.