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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...

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Updated: Jul 19, 2026

Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis
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Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis

Published on: February 24, 2023

Cutaneous melioidosis.

Lynn Teo1, Yong-Kwang Tay, Kent J F Mancer

  • 1Division of Dermatology, Changi General Hospital, Singapore. lynnteohweeying@hotmail.com

Journal of the European Academy of Dermatology and Venereology : JEADV
|October 26, 2006
PubMed
Summary

Melioidosis, a serious infection caused by Burkholderia pseudomallei, can affect any organ. This case highlights systemic melioidosis presenting with varied cutaneous lesions, emphasizing the bacterium

Area of Science:

  • Infectious Diseases
  • Bacteriology
  • Dermatology

Background:

  • Melioidosis is an infection caused by Burkholderia pseudomallei, a gram-negative bacterium.
  • The disease is endemic in Southeast Asia and Northern Australia, with sporadic cases in temperate regions, often linked to travelers.

Observation:

  • Burkholderia pseudomallei can affect any organ, triggering acute inflammation and abscess formation.
  • Cutaneous manifestations of melioidosis are highly variable.

Findings:

  • This report details a case of systemic melioidosis in a male patient.
  • The patient presented with distinct cutaneous lesions indicative of the systemic infection.

Implications:

  • Understanding the diverse clinical presentations of melioidosis, including skin lesions, is crucial for timely diagnosis.

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  • Early recognition of systemic melioidosis is vital for effective treatment and patient outcomes.