Related Experiment Video
Updated: Jul 19, 2026
Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
Published on: December 23, 2022
[Transcatheter closure for patent ductus arteriosus in children]
Xiang-qian Shen1, Sheng-hua Zhou, Zhen-fei Fang
1Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha 410011, China. xiangqian19982008@yahoo.com.cn
Insights
Transcatheter closure of patent ductus arteriosus (PDA) using coils, Amplatzer duct occluders (ADO), or native occluders is safe and effective in children. This minimally invasive approach offers a viable alternative to traditional thoracic surgery.
Area of Science:
- Pediatric Cardiology
- Interventional Cardiology
- Medical Devices
Context:
- Patent ductus arteriosus (PDA) is a common congenital heart defect in children.
- Transcatheter closure has emerged as an alternative to surgical intervention.
- Evaluating different devices for PDA closure is crucial for optimizing outcomes.
Purpose:
- To assess the efficacy and safety of transcatheter closure for PDA in pediatric patients.
- To compare the outcomes of different closure devices: coils, Amplatzer duct occluder (ADO), and native produced occluders.
- To evaluate the long-term results and potential complications associated with these devices.
Summary:
- This study included 78 children (7 months–14 years) with PDA, treated with coils (16), ADO (9), or native occluders (53).
- Immediate post-procedure echocardiography showed complete occlusion in 76 cases, with minimal residual shunts in 2 coil-treated patients.
- Follow-up to 80 months demonstrated sustained closure in 77 cases, normalization of left ventricular size, and well-positioned occluders, indicating high success rates.
Impact:
- Transcatheter closure of PDA is a safe and effective procedure in children, comparable to surgical methods.
- The use of ADO, native occluders, and coils provides excellent long-term results with minimal invasiveness.
- This interventional technique reduces complications and adverse effects, offering a preferred treatment option for pediatric PDA.
Objective:
To evaluate the results of transcatheter closure for patent ductus arteriosus (PDA) by different devices in children.
Methods:
Seventy-eight cases of PDA in children (7 months to 14 years old), diagnosed by physical examination and transthoracic 2-dimensional echocardiography (TTE), were included in the study. The examination included the cardiac catheterization, photograph of the thoracic aorta and conventional technique of PDA closure. Among these patients, 16 were treated with coils, 9 with Amplatzer duct occluder (ADO), and 53 with native produced PDA occluders.
Results:
TTE examination on the next day of the operation showed that PDAs were completely occluded in 76 cases, while the other 2 cases treated by coil had minimal residual shunt. Sixty-four patients, who were detected enlargement of the left ventricle before the operation, showed obvious diminishment of the cardiac size. By the end of 3 months, TTE examination showed that the closure of PDA was complete, and the left ventricle size was normal in 77 cases, while one case treated with coil had minimal residual shunt, which persisted for more than 4 years. The 3 - 80 months follow-up showed that the closure of PDA was complete in 77 cases, the configurations of the left ventricle, the thoracic aorta,and the left pulmonary artery were all normal. The occluders were well remained in situ.
Conclusion:
The usual procedures of transcatheter closure for PDA are effective and safe with ADO, native produced occluders and coil in children. Interventional method, which shows minute insult, few complications, and few adverse effects, can substitute the thoracic surgery.
