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Updated: Jul 19, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

[Epstein-Barr virus hepatitis associated with icterus--a case report].

Predrag Canović¹, Olgica Gajović, Zoran Todorović

¹Medicinski fakultet, Klinicko-bolnicki centar Kragujevac. adam@kg.ac.yu

Medicinski Pregled

|October 28, 2006

Summary

Epstein-Barr virus infection (EBVI) can rarely cause acute hepatitis with jaundice, even without typical infectious mononucleosis symptoms. Early detection relies on specific antibodies and the Paul Bunnell Davidson test.

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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

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Published on: March 30, 2018

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Last Updated: Jul 19, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

Area of Science:

Hepatology
Virology
Immunology

Background:

Primary Epstein-Barr virus infection (EBVI) typically presents as asymptomatic seroconversion in children or infectious mononucleosis in adolescents/adults.
Diagnosis relies on serologic tests, including IgM class antibodies to EBV virus-capsid-antigen (EBV VCA) and the non-specific Paul Bunnell Davidson test for heterophile antibodies.

Observation:

This case report details a patient presenting with acute hepatitis and icterus solely due to EBVI.
The patient experienced prolonged fever but lacked characteristic symptoms of infectious mononucleosis, such as pharyngitis and lymphadenopathy.

Findings:

Etiologic diagnosis was confirmed by a positive Paul Bunnell Davidson test and the presence of specific IgM antibodies to EBV VCA.
The pathogenetic mechanism involves free radical-induced hepatic cell damage via lipid peroxidation, potentially due to autoantibodies against superoxide-dismutase.

Implications:

Icteric manifestations of EBV infection are uncommon but should be considered in the differential diagnosis of jaundice.
Understanding EBV's role in hepatitis aids in accurate diagnosis and management of unexplained liver injury.