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Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

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Related Experiment Video

Updated: Jul 19, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

[Waldemström s macroglobulinemia].

P Khosravi Shahi1, A del Castillo Rueda, V M Díaz Muñoz de la Espada

  • 1Servicios de Oncología Médica y Medicina Interna II, Hospital General Universitario Gregorio Marañón, Madrid. drkhosravi@hotmail.com

Anales De Medicina Interna (Madrid, Spain : 1984)
|October 28, 2006
PubMed
Summary

Waldenström s macroglobulinemia is a rare B-cell cancer. Treatment for symptomatic cases includes chemotherapy and rituximab, while plasmapheresis manages complications.

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Context:

  • Waldenström s macroglobulinemia (WM) is a rare B-cell lymphoproliferative disorder.
  • Characterized by bone marrow infiltration and IgM monoclonal gammopathy.
  • Requires differentiation from monoclonal gammopathy of undetermined significance and other IgM disorders.

Purpose:

  • To summarize the key features of Waldenström s macroglobulinemia.
  • To outline diagnostic considerations.
  • To present current treatment strategies and management of complications.

Summary:

  • WM involves lymphoplasmacytic lymphoma infiltration and IgM gammopathy.
  • Median survival is approximately 5 years.
  • Asymptomatic patients require no treatment; symptomatic cases are managed with chemotherapy (alkylating agents, nucleoside analogues) and rituximab.

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Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Published on: June 29, 2016

Related Experiment Videos

Last Updated: Jul 19, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
11:10

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Published on: June 29, 2016

  • Plasmapheresis is effective for hyperviscosity and neuropathies.

    • Impact:

    • Provides a concise overview for clinicians and researchers.
    • Highlights the importance of accurate diagnosis and tailored treatment.
    • Emphasizes the role of plasmapheresis in managing WM-related complications.