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Updated: Jul 19, 2026

Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation
Published on: December 26, 2017
[Non-steroidal anti-inflammatory agents--potential risks of use during pregnancy]
Jeanett Borregaard Larsen1, Steffen Thirstrup Pedersen
1Laegemiddelstyrelsen, Laegemiddelgodkendelsen, København S.
Abstract:
NSAID are among the most frequently prescribed drugs in women, but our knowledge of possible negative effects on the outcome of pregnancies is limited. Use of NSAID in the third trimester is contra-indicated due to well-described adverse events. Recent epidemiological studies have raised concern about a possible increased risk of early spontaneous abortion and cardiac malformations associated with use of NSAID in early pregnancy, but other studies have been unable to confirm these findings. As long as these uncertainties exist, use of NSAID should be discouraged throughout pregnancy.
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