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Related Experiment Video

Updated: Jul 19, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Homocysteine and large arteries.

Coen van Guldener¹, Coen D A Stehouwer

¹Department of Internal Medicine, Amphia Hospital, Breda , The Netherlands.

Advances in Cardiology

|November 1, 2006

Summary

High homocysteine levels are linked to cardiovascular risks, but lowering them hasn't consistently reduced major events. Further research is needed to clarify the relationship between homocysteine and arterial stiffness.

Area of Science:

Cardiovascular Science
Metabolic Disorders
Biochemistry

Background:

Elevated plasma homocysteine is associated with atherothrombotic disease in both rare metabolic disorders and the general population.
Hyperhomocysteinemia presents a significant, albeit modest, cardiovascular risk that may vary across different populations.
Proposed mechanisms include endothelial dysfunction, increased oxidative stress, impaired methylation, and altered protein structure.

Purpose of the Study:

To investigate the association between plasma homocysteine concentrations and atherothrombotic disease.
To evaluate the impact of homocysteine-lowering treatments on cardiovascular events.
To examine the heterogeneous results regarding plasma homocysteine and arterial stiffness.

Main Methods:

Related Experiment Videos

Last Updated: Jul 19, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Observational studies on individuals with inborn errors of homocysteine metabolism.

Population-based studies assessing cardiovascular risk.

Clinical trials of homocysteine-lowering interventions.

Studies analyzing plasma homocysteine levels and arterial stiffness parameters.

Main Results:

A consistent association between high homocysteine and atherothrombotic disease is observed.
Homocysteine-lowering treatments have not yet demonstrated a significant reduction in major cardiovascular events.
Studies on arterial stiffness parameters have yielded inconsistent findings.

Conclusions:

While high homocysteine is a risk factor for cardiovascular disease, its clinical impact and the efficacy of lowering treatments require further clarification.
The relationship between homocysteine and arterial stiffness remains uncertain due to heterogeneous study results.
Further research is warranted to fully understand the role of homocysteine in cardiovascular pathology and to optimize therapeutic strategies.