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Hedonic hot spots in the brain.

Susana Peciña1, Kyle S Smith, Kent C Berridge

  • 1Department of Psychology, University of Michigan, Ann Arbor, MI 48109-1109, USA. pesu@umich.edu

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
|November 3, 2006
PubMed
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Brain research reveals specific "hedonic hot spots" in the nucleus accumbens and ventral pallidum that amplify the pleasure of food rewards. Understanding these opioid-sensitive areas may help explain excessive consumption and eating disorders.

Area of Science:

  • Neuroscience
  • Neurobiology
  • Sensory Science

Background:

  • Hedonic 'liking' for sensory pleasures is crucial for reward processing.
  • Excessive reward 'liking' can lead to overconsumption and disorders like obesity.

Purpose of the Study:

  • To review recent advances in identifying brain substrates for food 'liking'.
  • To focus on opioid-sensitive 'hedonic hot spots' in reward circuitry.

Main Methods:

  • Review of drug microinjection studies.
  • Utilizing modern neuroscience tools like Fos plume mapping.

Main Results:

  • Opioid administration in the nucleus accumbens and ventral pallidum amplifies 'liking' for sweet tastes.
  • Hedonic hot spots within these areas are particularly effective at magnifying food reward 'liking'.

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Conclusions:

  • Hedonic hot spots in different brain regions likely interact within functional circuitry.
  • Understanding these hot spots is key to characterizing neural mechanisms of reward 'liking'.