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Stress and breast cancer: a systematic update on the current knowledge
Naja Rod Nielsen1, Morten Grønbaek
1National Institute of Public Health, Øster Farimagsgade 5A, 2.sal, DK-1399 Copenhagen K, Denmark. nrn@niph.dk
Nature Clinical Practice. Oncology
|November 3, 2006
Summary
Psychological stress does not appear to increase breast cancer risk. However, the impact of stress on breast cancer progression remains uncertain, requiring further investigation.
Area of Science:
- Oncology
- Psychoneuroimmunology
- Epidemiology
Background:
- Extensive research explores the link between psychological stress and breast cancer risk.
- Previous reviews yielded conflicting data, primarily focusing on stressful life events.
Purpose of the Study:
- To evaluate associations between different types of stress (life events, work-related, global) and breast cancer incidence/relapse.
- To synthesize findings from prospective studies on stress and breast cancer.
Main Methods:
- Systematic literature search, study selection, and critical appraisal.
- Focus on prospective studies examining psychological stress and breast cancer outcomes.
Main Results:
- Heterogeneity in stress conceptualization and measurement precluded quantitative synthesis.
- No clear evidence indicates stress increases breast cancer incidence.
Conclusions:
- Psychological stress does not seem to elevate breast cancer incidence risk.
- The effect of stress on breast cancer progression requires further research with robust methodologies.
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