Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

NATsDB: Natural Antisense Transcripts DataBase.

Yong Zhang1, Jiongtang Li, Lei Kong

  • 1Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University Beijing 100871, PR China.

Nucleic Acids Research
|November 4, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of a Novel Glycosyltransferase Prognostic Signature in Hepatocellular Carcinoma Based on LASSO Algorithm.

Frontiers in genetics·2022
Same author

Two-step modification (sodium dodecylbenzene sulfonate composites acid-base) of sepiolite (SDBS/ABsep) and its performance for remediation of Cd contaminated water and soil.

Journal of hazardous materials·2022
Same author

Multistimuli-Responsive Squaraine Dyad Exhibiting Concentration-Controlled Vapochromic Luminescence.

ACS applied materials & interfaces·2022
Same author

Fabrication of 3D GelMA Scaffolds Using Agarose Microgel Embedded Printing.

Micromachines·2022
Same author

Reclassification of <i>Enterobacter</i> sp. FY-07 as <i>Kosakonia oryzendophytica</i> FY-07 and Its Potential to Promote Plant Growth.

Microorganisms·2022
Same author

Three-Dimensional Microfilament Printing of a Decellularized Extracellular Matrix (dECM) Bioink Using a Microgel Printing Bath for Nerve Graft Fabrication and the Effectiveness of dECM Graft Combined with a Polycaprolactone Conduit.

ACS applied bio materials·2022
Same journal

Correction to 'scSuperAnnotator: A platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data'.

Nucleic acids research·2026
Same journal

Correction to 'Differentiable partition function calculation for RNA'.

Nucleic acids research·2026
Same journal

Deployment of non-canonical splicing in tunicate genomes is mediated by divergent U2AF function and changing m6A modification in U1 and U6 snRNA.

Nucleic acids research·2026
Same journal

Bacillus subtilis DnaB forms multiple protein-protein interactions essential for DNA replication initiation.

Nucleic acids research·2026
Same journal

Multiple forms of protein-protein and DNA binding are exhibited by BrxC from the BREX phage restriction system.

Nucleic acids research·2026
Same journal

Biosynthesis of glycosylated 5-hydroxycytosine in the DNA of diverse viruses.

Nucleic acids research·2026
See all related articles

Natural antisense transcripts (NATs) regulate gene expression and are linked to diseases. This study identified numerous sense-antisense (SA) gene pairs across species and created NATsDB, a comprehensive database for their study.

Area of Science:

  • Genomics
  • Transcriptomics
  • Bioinformatics

Background:

  • Natural antisense transcripts (NATs) are endogenous RNA molecules that can regulate gene expression.
  • NATs are often transcribed from the opposite strand of their sense gene partners and play roles in various biological processes and diseases.

Purpose of the Study:

  • To identify and catalog cis-encoded exon-overlapping sense-antisense (SA) gene pairs across multiple eukaryotic species.
  • To develop a comprehensive database (NATsDB) for accessing and analyzing these SA gene pairs and related genomic information.

Main Methods:

  • Utilized an improved whole-genome computational pipeline to identify SA gene pairs.
  • Collected and integrated data on gene structure, conservation, expression, and disease association for cataloged genes.

Related Experiment Videos

  • Developed NATsDB with interactive visualization and advanced search functionalities.

    • Main Results:

    • Identified a substantial number of SA gene pairs in humans (7356), mice (6806), flies (1554), and other eukaryotes (total 6534).
    • Established NATsDB, a comprehensive resource containing over 6,500 SA gene pairs, classified into six overlapping patterns.
    • Included extensive annotations such as poly(A) signals, conservation scores, repeat elements, and OMIM disease associations.

    Conclusions:

    • The identified SA gene pairs represent a significant component of eukaryotic genomes.
    • NATsDB provides a valuable, centralized resource for researchers studying the function, regulation, and disease implications of natural antisense transcripts.
    • The database facilitates further investigation into the roles of SA genes in biology and pathology.