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Related Experiment Video

Updated: Jul 19, 2026

Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts

Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts

Published on: February 11, 2014

Bladder-sparing approaches to invasive disease.

Jason A Efstathiou¹, Anthony L Zietman, Donald S Kaufman

¹Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Cox 3, Boston, MA 02114, USA. jefstathiou@partners.org

World Journal of Urology

|November 4, 2006

Summary

Bladder-sparing trimodality therapy offers a viable alternative to radical cystectomy for invasive bladder cancer, achieving comparable survival rates and preserving native bladder function.

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Published on: July 28, 2012

Area of Science:

Urology
Oncology

Background:

Radical cystectomy is the standard for invasive bladder cancer.
Bladder-sparing approaches show promise in selected patients.

Purpose of the Study:

To evaluate the efficacy and outcomes of bladder preservation using trimodality therapy.
To compare trimodality therapy with radical cystectomy for invasive bladder cancer.

Main Methods:

Trimodality therapy includes transurethral resection, radiation, and chemotherapy.
Careful cystoscopic surveillance and prompt cystectomy for recurrences are employed.

Main Results:

Complete response rates of 60-80% achieved with trimodality therapy.
5-year survival rates of 50-60% and intact bladder survival of 40-45% observed.
Long-term survival comparable to contemporary cystectomy series.

Conclusions:

Trimodality therapy is a legitimate alternative to radical cystectomy for select patients.
Bladder preservation maintains good quality of life.
Further optimization of trimodality therapy and toxicity reduction are future goals.