Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Coping with stress: cellular relaxation techniques.

Christian Hirsch1, Robert Gauss, Thomas Sommer

  • 1Max-Delbrück Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany.

Trends in Cell Biology
|November 7, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeling Active Particle Motion from Fluorescence Correlation Spectroscopy Data.

Analytical chemistry·2026
Same author

Semi-automated evaluation of the American Board of Orthodontics electronic cast-radiograph evaluation for assessing orthodontic treatment outcome : Reliability and agreement.

Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie·2026
Same author

Autophagy selectively clears ER in TNF-α-induced muscle atrophy.

Autophagy reports·2026
Same author

Structuring of the yeast endolysosomal pathway by the Rab5 guanine nucleotide exchange factors Muk1 and Vps9.

Molecular biology of the cell·2026
Same author

Tooth Eruption and Microbial Correlation in Pediatric Appendicitis: An Exploratory Case-Control Study.

Journal of clinical medicine·2025
Same author

Actin Polymerizing Motors to Assist Cytoskeleton-like Networks Formation in Artificial Cells.

ACS nano·2025
Same journal

Horizontal transfer of mitochondria in cancer: The physiology reborn in disease?

Trends in cell biology·2026
Same journal

Spindle errors: A stress test for epithelial robustness.

Trends in cell biology·2026
Same journal

Multicellular ecosystems: Linking cellular diversity to tissue function and disease.

Trends in cell biology·2026
Same journal

Orchestrating the signaling-bias at the protease-activated receptor, PAR1.

Trends in cell biology·2026
Same journal

Crashing by design: Utilizing DNA damage for MCC differentiation.

Trends in cell biology·2026
Same journal

The value of a shared lab: Our insights.

Trends in cell biology·2026
See all related articles

Cells possess a stress response to manage damaged proteins, which can involve eliminating faulty messenger RNA (mRNA) when protein repair is not feasible. This mechanism aids cellular adaptation to environmental stressors.

Area of Science:

  • Cellular biology
  • Molecular biology
  • Stress response mechanisms

Background:

  • Damaged proteins, caused by stressors like heat or oxidation, pose risks to cellular health.
  • Cells activate stress responses to repair or eliminate misfolded proteins.
  • This response facilitates adaptation to adverse environmental conditions.

Purpose of the Study:

  • To investigate the mechanisms by which cells recognize and clear proteins that interfere with the protein folding machinery.
  • To explore whether cellular clearance mechanisms extend beyond the protein level.

Main Methods:

  • Analysis of cellular stress response pathways.
  • Investigation of protein recognition and degradation processes.
  • Examination of mRNA regulation during cellular stress.

Related Experiment Videos

Main Results:

  • Misfolded proteins trigger a cellular stress response.
  • This response includes pathways for repairing or eliminating defective proteins.
  • Cellular stress responses can also lead to the degradation of the messenger RNA (mRNA) of proteins that resist proper folding.

Conclusions:

  • Cellular stress response is a multifaceted system for maintaining protein homeostasis.
  • Clearance mechanisms are not limited to protein degradation but can also involve mRNA elimination.
  • Targeting mRNA offers a novel strategy for managing cellular stress and protein misfolding.