STAT module can function as a biphasic amplitude filter

V Mayya1, L M Loew

  • 1Department of Cell Biology and Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington 06030, USA. les@volt.uchc.edu

Systems Biology
|November 10, 2006
PubMed
Summary

Signal transducer and activator of transcription (STAT) proteins act as crucial mediators in cellular signaling pathways. Computational modeling reveals STATs function as a biphasic amplitude filter, amplifying signals within a specific range, with dimerization being key.

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