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Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
Published on: January 7, 2019
Preparation of nanoparticles by solvent displacement using a novel recirculation system
Elizabeth Piñón-Segundo1, Adriana Ganem-Quintanar, Juan Rafael Garibay-Bermúdez
1Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Cuautitlán Izcalli, Estado de México, México.
Pharmaceutical Development and Technology
|November 15, 2006
Summary
A new recirculation device improves poly(epsilon-caprolactone) nanoparticle production. This method offers comparable entrapment efficiency to conventional techniques, yielding acceptable results at lower polymer concentrations.
Area of Science:
- Materials Science
- Chemical Engineering
- Nanotechnology
Background:
- Poly(epsilon-caprolactone) (PCL) nanoparticles are crucial in drug delivery.
- Efficient and scalable methods for nanoparticle synthesis are needed.
Purpose of the Study:
- To develop and evaluate a novel recirculation device for preparing submicron PCL colloidal suspensions.
- To investigate the impact of process parameters on nanoparticle size and yield.
Main Methods:
- Solvent displacement method with a conventional approach and a new recirculation device.
- Analysis of organic solution injection rate, polymer concentration, and recirculation rate.
- Statistical analysis using ANOVA (alpha = 0.05).
Main Results:
- Nanoparticle sizes ranged from 156 to 381 nm.
- Optimizing parameters for smaller sizes decreased yield; acceptable yields (83-96%) were achieved at 2.5% PCL.
- Recirculation system variables significantly influenced particle size and yield.
Conclusions:
- The recirculation device is a viable method for PCL nanoparticle preparation.
- Entrapment efficiencies were comparable between the conventional and recirculation methods.
- The study highlights the trade-off between nanoparticle size and yield, influenced by process parameters.
