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An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
Published on: July 1, 2020
Risk factors for nosocomial candiduria
Selma Guler1, Onur Ural, Duygu Findik
1Department of Infectious Diseases, Konya Meram Training and Research Hospital, Konyas, Turkey. selmaguler38@yahoo.co.uk
Saudi Medical Journal
|November 16, 2006
Summary
Hospitalized patients face increased risk of candiduria, a fungal infection, due to factors like urinary catheterization and antibiotic use. Candida albicans is the most common cause, necessitating reduced catheter use and judicious antibiotic administration.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Epidemiology
Background:
- Candiduria, a fungal presence in urine, is a concern in hospitalized patients.
- Identifying risk factors and causative Candida species is crucial for effective management.
Purpose of the Study:
- To investigate risk factors associated with candiduria in hospitalized patients.
- To identify the prevalent Candida species causing candiduria in this population.
Main Methods:
- A case-control study was conducted involving hospitalized patients from January to December 2004.
- Cases had fever, pyuria, and no bacterial growth; controls had no bacterial growth post-hospitalization.
- Urine analysis results from 51 cases and 153 controls were evaluated.
Main Results:
- Significant risk factors for candiduria included abdominal surgery (OR=4.020), urinary catheterization (OR=12.408), and antibiotic use (OR=6.00).
- Diabetes mellitus (OR=2.002) and corticosteroid/immunosuppressive therapies (OR=1.478) also increased risk.
- Candida albicans was the most frequently isolated species (68.62%).
Conclusions:
- Urinary catheterization and antibiotic overuse are significant contributors to candiduria.
- Reducing urinary catheter use and optimizing antibiotic administration are recommended strategies.
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