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Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
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[Thrombophilia and patent foramen ovale in young stroke patients]

F J Carod-Artal1, S Vilela Nunes, D Portugal

  • 1Servicio de Neurología, Hospital Sarah Centro, Red Sarah de Hospitales de Rehabilitación, Brasilia DF. fjavier4644@terra.com.br

Neurologia (Barcelona, Spain)
|November 16, 2006
PubMed

Insights

Patent foramen ovale (PFO) is a vascular risk factor in young stroke patients. Thrombophilia is not an additional risk factor for cryptogenic stroke in young patients with PFO.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Genetics

Context:

  • Patent foramen ovale (PFO) is a recognized vascular risk factor in young stroke patients.
  • The role of thrombophilia in cryptogenic stroke with PFO remains unclear.
  • This study investigates the prevalence of thrombophilia in young stroke patients with PFO.

Purpose:

  • To determine the prevalence of thrombophilia in young stroke patients with PFO.
  • To assess the association between PFO, thrombophilia, and cryptogenic stroke.
  • To evaluate migraine prevalence in relation to PFO status.

Summary:

  • A prospective study of 130 young stroke patients (mean age 34) found 32.3% had PFO.
  • PFO was significantly more common in cryptogenic stroke patients (41%) compared to known etiology stroke patients (14.3%).
  • Thrombophilia prevalence was similar across PFO-positive and PFO-negative groups, suggesting it's not an additional risk factor for cryptogenic stroke in PFO patients.

Impact:

  • Findings suggest that thrombophilia does not contribute to the increased risk of cryptogenic stroke in young patients with PFO.
  • This research helps refine risk stratification for young stroke patients.
  • Understanding the interplay between PFO and thrombophilia is crucial for stroke prevention strategies.
Abstract

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