Multi-modality molecular imaging of tumors
Inna Serganova1, Ronald G Blasberg
1Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
Hematology/Oncology Clinics of North America
|November 23, 2006
Summary
Noninvasive molecular-genetic imaging visualizes biological processes in vivo. This technique aids in understanding cancer development and treatment response, with future clinical applications anticipated.
Area of Science:
- Biomedical imaging
- Molecular biology
- Genetics
Background:
- Noninvasive in vivo molecular-genetic imaging combines nuclear, magnetic resonance, and optical techniques.
- It enables direct imaging of molecules and pathways, indirect reporter gene imaging, and biomarker imaging.
Purpose of the Study:
- To demonstrate applications of positron emission tomography (PET) and optical reporter imaging.
- To showcase utility in studying oncogenesis, endogenous properties, and therapy response in animal models.
Main Methods:
- Utilizes nuclear, magnetic resonance, and optical imaging modalities.
- Employs direct, indirect (reporter gene), and biomarker imaging strategies.
- Applies techniques to genetic mouse models and animal models of human disease.
Main Results:
- Demonstrated PET- and optical-based reporter imaging applications.
- Successfully imaged oncogenesis and endogenous molecular-genetic-biological properties.
- Visualized response to therapy in animal models of human disease.
Conclusions:
- Molecular imaging provides spatial and temporal insights into oncogenesis and cancer progression.
- These studies complement traditional ex vivo assays by adding dynamic dimensions.
- Future translation to clinical settings is expected in the near future.
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