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Craniofacial cleft: a case of Tessier no. 3, 7 and 11 cleft
F Bodin1, B Salazard, J Bardot
1Department of Paediatric Plastic Surgery, Timone Children's Hospital, Marseille, France.
Insights
This study reports a rare case of craniofacial clefts (Tessier no. 3, 7, and 11) on the right side, associated with cardiac malformation. This specific combination of facial clefts and cardiac defect has not been previously documented in medical literature.
Area of Science:
- Craniofacial Surgery
- Pediatric Cardiology
- Medical Genetics
Background:
- Facial clefts are congenital conditions with varying incidence rates.
- Craniofacial clefts, particularly rare types like Tessier no. 3, 7, and 11, present unique diagnostic and surgical challenges.
- Cardiac malformations frequently co-occur with craniofacial anomalies, necessitating a multidisciplinary approach.
Observation:
- A rare case of right-sided craniofacial clefts involving Tessier classifications 3, 7, and 11 is presented.
- The patient exhibited a coexisting cardiac malformation, adding complexity to the clinical picture.
- Detailed review of epidemiology, classification, embryology, and pathogenesis of craniofacial malformations was conducted.
Findings:
- The specific association of Tessier no. 3, 7, and 11 craniofacial clefts with cardiac malformation is reported for the first time in the literature.
- Epidemiological data indicates facial cleft incidence ranges from 1.43 to 4.85 per 100,000 births.
- The embryological and pathogenic mechanisms underlying this complex malformation syndrome are discussed.
Implications:
- This case highlights the importance of thorough cardiac evaluation in patients with complex craniofacial clefts.
- Understanding rare craniofacial anomalies and their associations can improve diagnostic accuracy and treatment strategies.
- Further research into the genetic and environmental factors contributing to such combined malformations is warranted.
Abstract:
The incidence of the rare facial clefts is between 1.43 and 4.85 per 100.000 births. We report a case of right associated Tessier no. 3, 7 and 11 craniofacial clefts with cardiac malformation. The epidemiology, classification, embryology and pathogenesis of each craniofacial malformation are briefly reviewed. After an extensive review of the literature, we conclude that this association has not previously been reported.
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