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Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro
10:05

Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro

Published on: January 25, 2017

GMP-140: a receptor for neutrophils and monocytes on activated platelets and endothelium

R P McEver1

  • 1Department of Medicine, St. Francis Medical Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City.

Journal of Cellular Biochemistry
|February 1, 1991
PubMed

Insights

Platelet activation causes GMP-140 (granulocyte-macrophage progenitor-140) to move to the cell surface, where it acts as a receptor for leukocytes. This molecule plays a role in inflammation and may be a target for new therapies.

Area of Science:

  • Cell Biology
  • Immunology
  • Molecular Biology

Background:

  • GMP-140 is a membrane glycoprotein found in platelets and endothelial cells.
  • Activation of these cells leads to GMP-140 translocation to the plasma membrane.

Purpose of the Study:

  • To describe the structure and function of GMP-140.
  • To elucidate the role of GMP-140 in leukocyte adhesion and inflammatory processes.

Main Methods:

  • The study describes the molecular structure of GMP-140 and its family, the selectins.
  • It discusses the cellular localization and translocation of GMP-140 upon cell activation.
  • The research highlights GMP-140's function as a receptor for neutrophils and monocytes.

Main Results:

  • GMP-140 is a member of the selectin family, characterized by specific protein domains.
  • Upon activation, GMP-140 is expressed on the surface of platelets and endothelium.
  • GMP-140 mediates the adhesion of leukocytes to the blood vessel wall, particularly at sites of injury or inflammation.

Conclusions:

  • GMP-140 functions as a key adhesion molecule regulating leukocyte interactions with activated platelets and endothelium.
  • Its role in inflammation, thrombosis, and metastasis suggests potential as a therapeutic target for blocking adhesive receptor function in disease.

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