Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evolution at the host-retrovirus interface.

Robert J Gifford1

  • 1Division of Infectious Diseases, Stanford University, Stanford, California, CA 94305, USA. rjmg@stanford.edu

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|November 23, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ZNF274 constrains lineage plasticity and drives intrinsic resistance to CDK7 inhibitors in pancreatic cancer.

Nature communications·2026
Same author

Development of evolutionarily conserved viral integration sites as safe harbors for human gene therapy.

iScience·2025
Same author

Pervasive horizontal transfer of adeno-associated virus capsid genes.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Expression and Localization of a New Parvovirus-Derived Protein in the Guinea Pig.

Viruses·2025
Same author

2024 taxonomy update for the family Retroviridae.

Archives of virology·2025
Same author

No evidence that mutations in SARS-CoV-2 variants of concern derive from homologous fragments in gut microbiota.

Journal of virology·2024
Same journal

AI in Genomics: From Variant Calling to Multi-Omics Integration.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Rethinking One Health: Microbial Foundations for Ecological Governance.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Biobanked Liver Organoids: A Roadmap for Precision Hepatology.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

The Temporal Architecture of Human Cells: Organelle Clocks and Distributed Circadian Time.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Opposing Activity at the Apical Surface: An Antagonistic Collaboration Between Crumbs and Myosin II Determines Organ Shape.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Hidden Fungal DNA Structures May Shape Sequencing Outcomes.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
See all related articles

Retroviruses can integrate into host DNA and be passed to offspring. Studying retroviral diversity in vertebrate genomes reveals evolutionary patterns and ongoing invasions, alongside defense mechanisms.

Area of Science:

  • Evolutionary biology
  • Virology
  • Genomics

Background:

  • Retroviruses integrate into host genomes and transmit vertically.
  • Vertebrate genomes contain diverse retroviral sequences from repeated invasions.
  • Retroviral evolution has significant evolutionary consequences.

Purpose of the Study:

  • To detail retroviral diversity across vertebrate genomes.
  • To understand patterns of retroviral genome invasion and evolution.
  • To investigate innate antiretroviral defense mechanisms.

Main Methods:

  • Analysis of retroviral sequences within vertebrate genomes.
  • Comparative genomics to identify patterns of diversity.
  • Studies of ongoing retroviral genome invasion in wild populations.

Related Experiment Videos

  • Characterization of innate antiretroviral defense mechanisms.

    • Main Results:

    • A detailed picture of retroviral diversity has emerged over the past decade.
    • Striking and informative patterns of retroviral diversity differ across species.
    • Ongoing genome invasion in wild populations has been identified.
    • Conserved mechanisms of innate antiretroviral defense have been characterized.

    Conclusions:

    • Retroviral diversity in vertebrate genomes provides insights into retroviral biology and evolution.
    • Ongoing invasions and defense mechanisms are key aspects of the retrovirus-host dynamic.
    • Understanding these patterns is crucial for evolutionary and virological research.