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Uric acid in patients with angiographically documented coronary heart disease

Tonny Studsgaard Petersen1, Troels Vestergaard Madsen, Janus Bo Jespersen

  • 1Department of Preventive Cardiology, Center of Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark.

Acta Cardiologica
|November 23, 2006
PubMed

Insights

High uric acid levels are not an independent risk factor for coronary heart disease (CHD). While associated in women, this link disappears when considering other factors, suggesting uric acid is a marker, not a cause.

Area of Science:

  • Cardiovascular Medicine
  • Metabolic Disorders
  • Epidemiology

Background:

  • High serum uric acid levels are linked to coronary heart disease (CHD).
  • Hyperuricemia correlates with known CHD risk factors like obesity, insulin resistance, dyslipidemia, and hypertension.
  • The independent role of uric acid in CHD etiology remains unclear.

Purpose of the Study:

  • To investigate whether serum uric acid is an independent risk factor for coronary heart disease (CHD).

Main Methods:

  • Enrolled 290 patients undergoing coronary angiography for suspected CHD.
  • Examined the association between uric acid levels and angiographically confirmed coronary stenosis (>50% in major arteries).
  • Analyzed data for associations in men and women, with and without adjustment for confounders.

Main Results:

  • A significant association between high uric acid and coronary artery disease was found in women (p=0.02), but not in men (p=0.25).
  • After adjusting for confounders (smoking, triglycerides, HDL cholesterol, diabetes), the association in women was no longer significant.
  • This suggests uric acid's association with CHD is likely mediated by other factors.

Conclusions:

  • Serum uric acid is not an independent risk factor for coronary heart disease.
  • Uric acid may serve as a biological marker reflecting other underlying causative factors for CHD.
  • Clinical focus should remain on established risk factors rather than solely on uric acid levels.
Abstract

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